Research Emphasis Dr. Staveley-O’Carroll has a broad background in all phases of therapy development and implementation: leading multidisciplinary cancer-care teams, leading large National Cancer Institute and VA Grants with multiple investigators, and leading investigator-initiated clinical trials. His clinical expertise is focused on liver, pancreas, and foregut tumors, and his research and therapy-development activities center around
Read MoreResearch Emphasis Our laboratory is focused on physiologic signaling networks and how they function in molecular and cellular immunity. A main goal is to increase understanding of how T cells of the immune system decide whether to destroy or tolerate healthy, infected or cancerous tissue, with an eye toward applying lessons learned to design immunotherapies.
Read MoreResearch Emphasis: Dr. Guangfu Li is studying liver fibrosis, liver cancer, pancreatic cancer and lung cancer. Using cells, animal models and human biopsies, Dr. Li focuses on elucidating the underlying mechanisms mediating fibrosis, tumor growth and metastasis and tumor-induced immune tolerance. Based on the findings, Dr. Li aims to develop effective molecularly targeted diagnosis, molecularly targeted
Read MoreFields of Interest Cellular Immunology Education Ph.D. 1987, University of Paris, France Research Statement T cells in Immunity and Autoimmunity. Four research projects that focus on the biology of T cells and their role in immunity and autoimmunity are being pursued in my laboratory. The first, concerns investigation of the mechanism by which myelin-reactive T
Read MoreFields of Interest Cellular and Molecular Immunology Education Ph.D., 2001, Michigan State University Research Statement T Cell Tolerance, Autoimmunity, Epigenetics, and Regulation of T Cell Differentiation The goal of our laboratory is directed towards the prevention and treatment of human autoimmune disorders, inflammatory diseases, and cancer. TGF-b is a family of secreted proteins that have
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