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Stephanie McKay

Stephanie McKay

Associate Professor of Genetic and Genomics

Animal Sciences,

stephanie.mckay@missouri.edu

(573) 884-1417

Research Emphasis

The overarching goal of the McKay lab is to utilize the latest advances in biotechnology while developing new methodologies and resources to determine the extent to which epigenetic and epitranscriptomic modifications contribute towards economically important traits in livestock. While many epigenetic modifications exist, her current research focus is on 5-Methylcytosine, 5-Hydroxymethylcytosine and N6-Methyladenosine. The context in which her lab studies these modifications include neuroepigenomics, comparative epigenomics and functional annotation.

Research Interests

  • Epigenetics
  • Livestock genetics
  • Genomics

Education

PhD 2007 Animal Sciences – University of Alberta
MS 2002 Veterinary Pathobiology – Texas A&M University
BS 1999 Biochemistry, Genetics – Texas A&M University

Selected Publications

McKendrick, EP Fuller, NE Cockett, JE Koltes, SD McKay, JA Green, BM Murdoch, DE Hagen, and CG Elsik. 2023. AgAnimalGenomes: browsers for viewing and manually annotating farm animal genomes. Mammalian Genome. doi: https://doi.org/10.1007/s00335- 023-10008-1

Tuggle, CK, JL Clarke, BM Murdoch, E Lyons, NM Scott, B Benes, JD Campbell, SD Choudhury. H Chung, CL Daigle, JCM Dekkers, JRR Dorea, DS Ertl, M Feldman, BO, Fragomeni, JE Fulton, CR Guadagno, DE Hagen, AS Hess, LM Kramer, CJ Lawrence-Dill, AD Lipka, T Lubberstedt, FM McCarthy, SD McKay, SC Murray, PK Riggs, TN Rowan, MJ, Sheehan, JP Steible, SM Thompson, KJ, Thorton, CP Van Tassell and PS Schanble. 2023. Current Challenges and Future of Agricultural Genomes to Phenomes. Genome Biology. https://doi.org/10.1186/s13059-023-03155-w

Beiki, H, BM Murdoch, CA Park, C Kern, D Kontechy, G Becker, G Ricon, H Jiang, H, Zhou, J Thorne, JE Koltes, JJ Michal, K Davenport, M Rijnkles, PJ ross, R Hu, S Corum, S, McKay, TPL Smith, W Liu, W Ma, X Zhang, X Xu, X Han, Z Jiang, Z Hu, and JM Reecy. Functional genomics of cattle through integration of multi-omics data. bioRxiv 2022.10.05.510963; doi: https://doi.org/10.1101/2022.10.05.510963 GigaScience, In Review

Ben Zaabza, H, CP Van Tassell, J Vandenplas, P VanRaden, Z Liu, H Eding, S McKay, K, Haugaard, MH Lidauer, EA Mäntysaari. I Strandén. 2022. Invited review: Reliability computation from the animal model era to the single-step genomic model era. Journal of Dairy Science. https://doi.org/10.3168/jds.2022-22629

Rosenblatt, E, K Gieder, T Donovan, J Murdoch, TPL Smith, M Heaton, T Kalbfleisch, B Murdoch, S Bhattarai, E Pacht E Verbist, V Basnayake and S McKay. 2023. Genetic Diversity and Connectivity of Moose (Alces americanus americanus) in eastern North
America. Conservation Genetics. https://doi.org/10.1007/s10592-022-01496-w

Ibeagha-Awemu, E.M., N. Bissonnette, S. Bhattarai, M. Wang, P.-L. Dedemaine, S.D. McKay, X. Zhao. 2021.Whole Genome Methylation Analysis Reveals Role of DNA Methylation in Cow’s Illeal and Illeal Lymph Node Responses to Mycobacterium avium subsp. paratuberculosis Infection. Frontiers in Genetics. DOI:10.3389/fgene.2021.797490

Pacht, Emory, Brenda Murdoch, and Stephanie McKay. 2021. Examining the extent of environmental contributions towards DNA methylation and phenotypic variation. Animal Frontiers. 11(6):83-89

Davenport, KM, AT Massa, S Bhattarai, SD McKay, MR Mousel, MK Herndon, SN White, N Cockett, TPL Smith, BM Murdoch. 2021, Characterizing Genetic Regulatory Elements in Ovine Tissues. Frontiers in Genetics. 12: 566 https://doi.org/10.1093/af/vfab056

Brevik, K, EM Bueno, S McKay, SD Schoville, and YH Chen. 2020. Insecticide exposure affects intergenerational patterns of DNA methylation in the Colorado potato beetle, Leptinotarsa decemlineata. Evol Appl. 2020; 00: 1– 12. https://doi.org/10.1111/eva.13153

Rosen, B.D., D.M. Bickhart, R.D. Schnabel, S. Koren, C.G. Elsik, E. Tseng, T.N. Rowan, W.Y. Low, A. Zimin, C. Couldrey, R. Hall, W. Li, A. Rhie, J. Ghurye, S.D. McKay, F. Thibaud-Nissen, J. Hoffman, B.M. Murdoch, W.M. Snelling, T.G. McDaneld, J.A. Hammond, J.C. Schwartz, W. Nandolo, D.E. Hagen, C. Dreischer, S.J. Schultheiss, S.G. Schroeder, A.M. Phillippy, J.B. Cole, C.P.V. Tassell, G. Liu, T.P.L. Smith, and J.F. Medrano. 2019. De novo assembly of the cattle reference genome with single-molecule
sequencing GigaScience. 9 (3). https://doi.org/10.1093/gigascience/giaa021

Davenport, K., C. Hiemke, S.D. McKay, J. Thorne, R. Lewis, T. Taylor, and B.M. Murdoch. Genetic Structure and Admixture in Sheep from Terminal Breeds in the United States. Animal Genetics. 51(2): 284-291.