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Shiyou Chen

Shiyou Chen

Professor of Surgery



Research Emphasis:

Dr. Chen has a broad research interest in vascular biology. He has been studying molecular mechanisms underlying the development of a number of vascular diseases including abdominal aortic aneurysm, atherosclerosis, hypertension, restenosis and vascular remodeling following vascular injury such as angioplasty, etc. His efforts have been largely directed to investigate vascular smooth muscle phenotypic modulation during artery wall remodeling in pathological conditions. Dr. Chen also studies vascular inflammation, endothelial dysfunction, and metabolic disorders including obesity and fatty liver diseases. His laboratory uses a variety of molecular and cellular technology as well as animal models and human biopsies to address fundamental questions in disease development.

Research Interests

  • Vascular smooth muscle phenotypic modulation
  • Vascular remodeling
  • Atherosclerosis
  • Aortic aneurysm formation
  • Hypertension
  • Fatty liver disease
  • Asthma


  • Ph.D. 1993, Nanjing Agricultural University, Nanjing, and Shanghai Institute of Biochemistry, Chinese Academy of Science, Shanghai, China

Selected Publications

  1. Jun-Ming Tang, Ning shi, Kun Dong, Scott A. Brown, Amanda E. Coleman, Matthew A. Boegehold, Shiyou Chen, Response gene to complement 32 maintains blood pressure homeostasis by regulating α-adrenergic receptor expression, Circulation Research, 123:1080-1090, 2018
  2. Xiao-Bing Cui, Jun-Na Luan, Kun Dong, Sisi Chen, Yongyi Wang, Wendy T. Watford, and Shiyou Chen, RGC-32 deficiency protects endothelial cell from inflammation and attenuates atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), 38: e36-e47, 2018
  3. Chenming Sun & Shiyou Chen, RGC32 promotes bleomycin-induced systemic sclerosis in a murine disease model by modulating classically activated macrophage function, Journal of Immunology, 200(8):2777-2785, 2018
  4. Rui Tang, Gui Zhang, Yung-chun Wang and Shiyou Chen, Long non-coding RNA GAS5 regulates TGF-β-induced smooth muscle cell differentiation through intrinsic rSBE elements, Journal of Biological Chemistry (JBC),292(34):14270-14278, 2017
  5. Ning Shi, Jing Zhang and Shiyou Chen, Runx2, a novel regulator for goblet-cell differentiation and asthma development, FASEB Journal, 31(1): 412-420, 2017
  6. Xia Guo, Feifei Li, Zaiyan Xu, Shiyou Chen, DOCK2 deficiency mitigates high-fat diet-induced obesity by reducing adipose tissue inflammation while increasing energy expenditure, Journal of Lipid Research, 58(9):1777-1784, 2017
  7. Jia Fei, Xiao-Bing Cui, Jia-Ning Wang, Kun Dong, and Shiyou Chen, ADAR1-mediated RNA editing, A novel mechanism controlling phenotypic modulation of vascular smooth muscle cells, Circulation Research, 119:463-469, 2016 (Accompanying Editorial: Circulation Research, 119:401-403, 2016)
  8. Xia Guo, Xiao-Bing Cui, Jia-Ning Wang, Ning Shi, Yoshinori Fukui, Shiyou Chen, Dedicator of cytokinesis 2, a novel regulator for vascular smooth muscle phenotype and vascular remodeling, Circulation Research, 116: e71-e80, 2015;
  9. Xiaobing Cui, Junna Luan, Shiyou Chen, RGC-32 deficiency protects against hepatic steatosis by reducing lipogenesis, Journal of Biological Chemistry (JBC), 290(33):20387-95, 2015
  10. Ning Shi, Xia Guo, Shiyou Chen, Olfactomedin 2, a novel regulator for transforming growth factor-β-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells, Molecular Biology of Cell, 25 (25): 4106-14, 2014
  11. Weibing Xie, Zuguo Li, Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Yang Chai, Erwin P Bottinger, Pedro A Jose, Shiyou Chen, Smad2 and MRTFB cooperatively regulate vascular smooth muscle differentiation from neural crest cells, Circulation Research, 113(8): e76-86, 2013 (Accompanying Editorial:Circulation Research 113: 946-948, 2013)
  12. Rui Tang, Xiao-Bing Cui, Jia-Ning Wang and Shiyou Chen, CTP synthase, a smooth muscle-sensitive therapeutic target for effective vascular repair, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), 33(10):2336-44, 2013 (Accompanying Editorial: ATVB 33(10):2286-7, 2013, AHA news:
  13. Xiao-Bing Cui, Xia Guo and Shiyou Chen, Response gene to complement 32-deficiency causes impaired placental angiogenesis in mice, Cardiovascular Research, 99(4):632-9, 2013
  14. Ning Shi, Weibing Xie, Shiyou Chen, Cell division cycle 7 is essential for the initiation of transforming growth factor-β-induced smooth muscle differentiation, Journal of Biological Chemistry (JBC), 287(9):6860–6867, 2012
  15. Jianing Wang, Ning Shi, Shiyou Chen, Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), 31(8): e19-26, 2011
  16. Wenyan Huang, Zuguo  Li, Horea Rus, Xiaoyan Wang, Pedro A Jose, Shiyou Chen, Response gene to complement 32 mediates transforming growth factor beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells, Journal of Biological Chemistry (JBC), 284(14):9426-32, 2009
  17. Fengmin Li, Zaiming Luo, Wenyan Huang, Quansheng Lu, Christopher S Wilcox, Pedro A Jose and Shiyou Chen,Respose gene to complement 32, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of neural crest cells, Journal of Biological Chemistry (JBC), 282(14):10133-7, 2007
  18. Shiyou Chen, Michelle Crawford, Regina M. Day, Victorino R. Briones, Jennifer E. Leader, Pedro A. Jose and Robert J. Lechleider, RhoA modulates Smad signaling during TGF-beta-induced smooth muscle differentiation, Journal of Biological Chemistry (JBC), 281(3):1765-70, 2006
  19. Shiyou Chen and Robert J. Lechleider, Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest cell line, Circulation Research, 94: 1195-1202, 2004
  20. Shiyou Chen, Magdalena Kulik and Robert J. Lechleider, Smad proteins mediate transcription of smooth muscle marker gene SM22alpha, Nucleic Acid Research, 31(4): 1302-10, 2003