To The Top
Martin L. Katz

Martin L. Katz

Ophthalmology,

Professor of Ophtalmology and Director of the Neurodegenerative Diseases Research Laboratory

katzm@health.missouri.edu

(573)882-8480

Lab website link

Research Interest

  • Neurodegenerative diseases

Education

Ph.D. Marquette University, University of California, Santa Cruz

Selected publications

Ru Y, Corado C, Soon RK, Melton AC, Harris A, Yu GK, Pryer N, Sinclair JR, Katz ML, Ajayi T, Jacoby D, Russell CB, Chandriani S.  Neurofilament light is a treatment-responsive biomarker in CLN2 disease.  Annals of Clinical and Translational Neurology 6:2437-2447, 2019.  https://onlinelibrary.wiley.com/doi/epdf/10.1002/acn3.50942

Guo J, Johnson GS, Cook J, Harris OK, Mhlanga-Mutangadura T, Schnabel RD, Jensen CA, Katz ML.  Neuronal ceroid lipofuscinosis in a German Shorthaired Pointer associated with a previously reported CLN8 nonsense variant.  Molec Genet Metabol Reports 21:100521, 2019. https://www.sciencedirect.com/science/article/pii/S2214426919301636

Villani NA, Bullock G, Michaels JR, Yamato O, O’Brien DP, Mhlanga-Mutangadura T, Johnson GS, Katz ML.  A mixed breed dog with neuronal ceroid lipofuscinosis is homozygous for aCLN5 nonsense mutation previously identified in Border Collies and Australian Cattle Dogs.  Molec Genet Metabol  127:107-115, 2019. https://www.sciencedirect.com/science/article/pii/S109671921930085X?via%3Dihub

Schmutz I, Jagannathana V, Bartenschlager F, Stein VM, Gruber AD, Leeb T, Katz ML.  ATP13A2 missense variant in Australian Cattle Dogs with late onset neuronal ceroid lipofuscinosis.  Molec Genet Metabol  127:95-106, 2019. https://www.sciencedirect.com/science/article/pii/S109671921830489X?via%3Dihub

Murgiano L, Becker D, Torjman D, Niggel JK, Milano A, Cullen C, Feng R, Wang F, Jagannathan V, Pearce-Kelling S, Katz ML, Leeb T, Aguirre GD.  Complex Structural PPT1 Variant Associated with Non-syndromic Canine Retinal Degeneration.  G3: Genes, Genomes, Genetics 9: 425-437, 2019. https://doi.org/10.1534/g3.118.200859

Katz ML, Rustad E, Robinson GO, Whiting REH, Student JT, Coates JR, Narfstrom K. Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions. Neurobiol Disease 108:277-287, 2017. http://www.sciencedirect.com/science/article/pii/S0969996117302073?via%3Dihub

Kolicheski, A, Johnson GS, Villani NA, O’Brien DP, Mhlanga-Mutangadura T, Wenger DA, Mikoloski K, Eagleson JS, Taylor JF, Schnabel RD, Katz ML. GM2 gangliosidosis in Shiba Inu dogs with an inframe deletion in HEXB. J Vet Internal Med 31:1520-1526, 2017. onlinelibrary.wiley.com/doi/10.1111/jvim.14794/full

Kolicheski A, Barnes Heller HL, Arnold S, Schnabel RD, Taylor JF, Knox CA, Mhlanga-Mutangadura T, O’Brien DP, Johnson GS, Dreyfus J, Katz ML Homozygous PPT1 splice donor mutation in a Cane Corso Dog with neuronal ceroid lipofuscinosis. J Vet Internal Med 31:149-157, 2017. http://onlinelibrary.wiley.com/doi/10.1111/jvim.14632/full

Katz ML, Johnson GC, Leach SB, Williamson BG, Coates JR, Whiting REH, Vansteenkiste DP, Whitney MS. Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression. Gene Ther 24: 215-223, 2017. http://www.nature.com/gt/journal/v24/n4/pdf/gt20174a.pdf

Tracy CJ, Whiting REH, Pearce JW, Williamson BG, Daniella P. Vansteenkiste DP, Gillespie LE, Castaner LJ, Bryan JN, Coates JR, Jensen CA, Katz ML. Intravitreal Implantation of TPP1-Transduced Stem Cells Delays Retinal Degeneration in Canine CLN2 Neuronal Ceroid Lipofuscinosis. Exp Eye Res 152:77-87, 2016. http://www.sciencedirect.com/science/article/pii/S0014483516302536

Ashwini A, D’Angelo A, Yamato O, Giordano C, Cagnotti G, Harcourt-Brown T, Mhlanga-Mutangadura T, Guo J, Johnson GS, Katz ML. Neuronal ceroid lipofuscinosis associated with an MFSD8 mutation in Chihuahuas. Molec Genet Metabol 118:326-332, 2016. http://www.sciencedirect.com/science/article/pii/S109671921630083X

Kolicheski A, Johnson GS, O’Brien DP, Mhlanga-Mutangadura T, Gilliam D, Guo J, Anderson-Sieg TD, Schnabel RD, Taylor JF, Lebowitz A, Swanson B, Hicks D, Niman ZE, Winninger FA, Carpentier MC, Katz ML. Australian Cattle Dogs with neuronal ceroid lipofuscinosis are homozygous for a CLN5 nonsense mutation previously identified in Border Collies. J Vet Internal Med 30:1149-1158, 2016. http://onlinelibrary.wiley.com/doi/10.1111/jvim.13971/epdf

Whiting REH, Jensen CA, Pearce JW, Castaner LJ, Gillespie LE, Bristow DE, Katz ML. Intracerebroventricular gene therapy that delays neurological disease progression is associated with selective preservation of retinal ganglion cells in a canine model of CLN2 disease. Exp Eye Res 146:276-282, 2016. http://www.sciencedirect.com/science/article/pii/S0014483516300550

Mhlanga-Mutangadura T, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Katz ML, Shelton GD, Lever TE, Giuliano E, Granger N, Shomper J, O’Brien DP. Black Russian Terrier dogs with polyneuropathy, ocular abnormalities, and neuronal vacuolation have a mutation in RAB3GAP1. Neurobiology of Disease 86:75-85, 2016. http://ac.els-cdn.com/S0969996115300930/1-s2.0-S0969996115300930-main.pdf?_tid=6fd08592-f110-11e5-a3c1-00000aab0f01&acdnat=1458749040_cfcdacb030851ceda65cfe250a792975

Katz ML, Tecedor L, Chen Y, Williamson BG, Lysenko E, Wininger FA, Young WM, Johnson GC, Whiting REH, Coates JR, Davidson BL. AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease. Science Translational Medicine 11 Nov 2015: Vol. 7, Issue 313, pp. 313ra180. DOI: 10.1126/scitranslmed.aac6191. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968409/

Gilliam D, Kolicheski A, Johnson GS, Mhlanga-Mutangadura T, Taylor JF, Schnabel RD, Katz ML. Golden Retriever dogs with neuronal ceroid lipofuscinosis have a two-base-pair deletion and frameshift in CLN5. Molec Genet Metabol 115: 101–109, 2015. http://www.sciencedirect.com/science/article/pii/S109671921500089X

Farias FH, Zeng R Johnson GS, Wininger FA, Taylor JF, Schnabel RD, McKay SD, Lohi H, Lindblad-Toh K, Wade CM, O’Brien DP, Katz ML. A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan Terriers Neurobiol Dis 42:468-474, 2011. (http://www.sciencedirect.com/science/article/pii/S0969996111000635)

Awano T, Johnson GS, Wade CM, Katz ML, Johnson GC, Taylor JF, Perloski M, Biagi T, Long S, March PA, Olby NJ, Khan S, O’Brien DP, Lindblad-Toh K and Coates JR. Genome-wide association analysis reveals a SOD1 mutation in Canine Degenerative Myelopathy: That Resembles Amyotrophic Lateral Sclerosis. Proc Nat Acad Sci USA PNAS 106 (8) 2473-2474. 2009 (http://dx.doi.org/10.1073/pnas.0812297106