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Martin L. Katz

Martin L. Katz

Professor of Ophtalmology and Director of the Neurodegenerative Diseases Research Laboratory



Lab website link

Research Interest

  • Neurodegenerative diseases


Ph.D. Marquette University, University of California, Santa Cruz

Selected publications

Ru Y, Corado C, Soon RK, Melton AC, Harris A, Yu GK, Pryer N, Sinclair JR, Katz ML, Ajayi T, Jacoby D, Russell CB, Chandriani S.  Neurofilament light is a treatment-responsive biomarker in CLN2 disease.  Annals of Clinical and Translational Neurology 6:2437-2447, 2019.

Guo J, Johnson GS, Cook J, Harris OK, Mhlanga-Mutangadura T, Schnabel RD, Jensen CA, Katz ML.  Neuronal ceroid lipofuscinosis in a German Shorthaired Pointer associated with a previously reported CLN8 nonsense variant.  Molec Genet Metabol Reports 21:100521, 2019.

Villani NA, Bullock G, Michaels JR, Yamato O, O’Brien DP, Mhlanga-Mutangadura T, Johnson GS, Katz ML.  A mixed breed dog with neuronal ceroid lipofuscinosis is homozygous for aCLN5 nonsense mutation previously identified in Border Collies and Australian Cattle Dogs.  Molec Genet Metabol  127:107-115, 2019.

Schmutz I, Jagannathana V, Bartenschlager F, Stein VM, Gruber AD, Leeb T, Katz ML.  ATP13A2 missense variant in Australian Cattle Dogs with late onset neuronal ceroid lipofuscinosis.  Molec Genet Metabol  127:95-106, 2019.

Murgiano L, Becker D, Torjman D, Niggel JK, Milano A, Cullen C, Feng R, Wang F, Jagannathan V, Pearce-Kelling S, Katz ML, Leeb T, Aguirre GD.  Complex Structural PPT1 Variant Associated with Non-syndromic Canine Retinal Degeneration.  G3: Genes, Genomes, Genetics 9: 425-437, 2019.

Katz ML, Rustad E, Robinson GO, Whiting REH, Student JT, Coates JR, Narfstrom K. Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions. Neurobiol Disease 108:277-287, 2017.

Kolicheski, A, Johnson GS, Villani NA, O’Brien DP, Mhlanga-Mutangadura T, Wenger DA, Mikoloski K, Eagleson JS, Taylor JF, Schnabel RD, Katz ML. GM2 gangliosidosis in Shiba Inu dogs with an inframe deletion in HEXB. J Vet Internal Med 31:1520-1526, 2017.

Kolicheski A, Barnes Heller HL, Arnold S, Schnabel RD, Taylor JF, Knox CA, Mhlanga-Mutangadura T, O’Brien DP, Johnson GS, Dreyfus J, Katz ML Homozygous PPT1 splice donor mutation in a Cane Corso Dog with neuronal ceroid lipofuscinosis. J Vet Internal Med 31:149-157, 2017.

Katz ML, Johnson GC, Leach SB, Williamson BG, Coates JR, Whiting REH, Vansteenkiste DP, Whitney MS. Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression. Gene Ther 24: 215-223, 2017.

Tracy CJ, Whiting REH, Pearce JW, Williamson BG, Daniella P. Vansteenkiste DP, Gillespie LE, Castaner LJ, Bryan JN, Coates JR, Jensen CA, Katz ML. Intravitreal Implantation of TPP1-Transduced Stem Cells Delays Retinal Degeneration in Canine CLN2 Neuronal Ceroid Lipofuscinosis. Exp Eye Res 152:77-87, 2016.

Ashwini A, D’Angelo A, Yamato O, Giordano C, Cagnotti G, Harcourt-Brown T, Mhlanga-Mutangadura T, Guo J, Johnson GS, Katz ML. Neuronal ceroid lipofuscinosis associated with an MFSD8 mutation in Chihuahuas. Molec Genet Metabol 118:326-332, 2016.

Kolicheski A, Johnson GS, O’Brien DP, Mhlanga-Mutangadura T, Gilliam D, Guo J, Anderson-Sieg TD, Schnabel RD, Taylor JF, Lebowitz A, Swanson B, Hicks D, Niman ZE, Winninger FA, Carpentier MC, Katz ML. Australian Cattle Dogs with neuronal ceroid lipofuscinosis are homozygous for a CLN5 nonsense mutation previously identified in Border Collies. J Vet Internal Med 30:1149-1158, 2016.

Whiting REH, Jensen CA, Pearce JW, Castaner LJ, Gillespie LE, Bristow DE, Katz ML. Intracerebroventricular gene therapy that delays neurological disease progression is associated with selective preservation of retinal ganglion cells in a canine model of CLN2 disease. Exp Eye Res 146:276-282, 2016.

Mhlanga-Mutangadura T, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Katz ML, Shelton GD, Lever TE, Giuliano E, Granger N, Shomper J, O’Brien DP. Black Russian Terrier dogs with polyneuropathy, ocular abnormalities, and neuronal vacuolation have a mutation in RAB3GAP1. Neurobiology of Disease 86:75-85, 2016.

Katz ML, Tecedor L, Chen Y, Williamson BG, Lysenko E, Wininger FA, Young WM, Johnson GC, Whiting REH, Coates JR, Davidson BL. AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease. Science Translational Medicine 11 Nov 2015: Vol. 7, Issue 313, pp. 313ra180. DOI: 10.1126/scitranslmed.aac6191.

Gilliam D, Kolicheski A, Johnson GS, Mhlanga-Mutangadura T, Taylor JF, Schnabel RD, Katz ML. Golden Retriever dogs with neuronal ceroid lipofuscinosis have a two-base-pair deletion and frameshift in CLN5. Molec Genet Metabol 115: 101–109, 2015.

Farias FH, Zeng R Johnson GS, Wininger FA, Taylor JF, Schnabel RD, McKay SD, Lohi H, Lindblad-Toh K, Wade CM, O’Brien DP, Katz ML. A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan Terriers Neurobiol Dis 42:468-474, 2011. (

Awano T, Johnson GS, Wade CM, Katz ML, Johnson GC, Taylor JF, Perloski M, Biagi T, Long S, March PA, Olby NJ, Khan S, O’Brien DP, Lindblad-Toh K and Coates JR. Genome-wide association analysis reveals a SOD1 mutation in Canine Degenerative Myelopathy: That Resembles Amyotrophic Lateral Sclerosis. Proc Nat Acad Sci USA PNAS 106 (8) 2473-2474. 2009 (