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Kevin Staveley-O’Carroll

Kevin Staveley-O’Carroll

Hugh E. Stephenson Professor of Surgery

Surgery,

ocarrollk@health.missouri.edu

573-882-8454

Research Emphasis

Dr. Staveley-O’Carroll has a broad background in all phases of therapy development and implementation: leading multidisciplinary cancer-care teams, leading large National Cancer Institute and VA Grants with multiple investigators, and leading investigator-initiated clinical trials. His clinical expertise is focused on liver, pancreas, and foregut tumors, and his research and therapy-development activities center around enhancing the immune response to these tumors.

Research Interests

  • Developing new cancer treatments
  • Investigating immunotherapeutic, chemotherapeutic, and nanoparticle agents in a variety of cancers

Education

  • PhD 2000, Pharmacology and Molecular Biology, The Johns Hopkins University School of Medicine
  • MD 1990, University of Oklahoma College of Medicine
  • BS 1986, Chemistry, University of Notre Dame

Selected Publications

Manjunath Y, Porciani D, Mitc hem JB, Suvilesh KN, Avella DM, Kimchi ET, Staveley-O’Carroll KF, Burke DH, Li G, Kaifi JT. Tumor-Cell-Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer, Int J Mol Sci. 2020 Mar 9; 21(5):1872. doi: 10.3390/ijms21051872. PMID: 32182935. PMCID: PMC7084898.

Tang R, Wang YC, Mei X, Shi N, Sun C, Ran R, Zang G, Li W, Staveley-O’Carroll KF, Li G, Chen SY. LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling, Am J Physiol Cell Physiol. 2020 Jul 1; 319(1): C105-C115. doi: 10.1152/ajpcell.00059.2020. Epub 2020 May 6. PMID: 32374674.

Manjunath Y, Mitchem JB, Suvilesh KN, Avella DM, Kimch ET, Staveley-O’Carroll KF, Deroche CV, Pantel K, Li G, Kaifi JT. Circulating Giant Tumor-Marcrophage Fusion Cells are Independent Prognosticators in Patients with NSCLC, Thorac Oncol. 2020 May 13: S1556-0864(20)30381-6. doi: 10.1016/j.tho.2020.04.034. Online ahead of print. PMID: 32416323

Avella DM, Manjunath Y, Singh A, Deroche CB, Kimchi ET, Staveley-O’Carroll KF, Mitchem JB, Kwon E, Li G, Kaifi JT. 18F-FDG PET/CT total lesion glycolysis is associated with circulating tumor cell counts in patients with stage I to IIIA non-small cell lung cancer. Transl Lung Cancer Res. 2020 Jun;9(3):515-521. doi: 10.21037/tlcr.2020.04.10. PMID: 32676315

 Xiaoqiang Qi, Ming Yang, Lixin Ma, Madeline Sauer, Diego Avella, Jussuf T. Kaifi, Jeffrey Bryan, Kun Cheng, Kevin F. Staveley-O’Carroll, Eric T. Kimchi, Guangfu Li, Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response, Journal for ImmunoTherapy of Cancer, 2020; 8: e001038. doi:10.1136/jitc-2020-001038

Xiaoqiang Qi, Ming Yang, Joseph Stenberg, Rahul Dey, Leslie Fogwe, Muhammad Shawkat Alam, Eric T Kimchi, Kevin F Staveley-O’Carroll and Guangfu Li, Gut microbiota mediated molecular events and therapy in liver diseases, World Journal of Gastroenterology, 2020, 26 (48): 7603-7618. doi: 3748/wjg.v26.i48.7603

Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng. Silencing PCBP2 Normalizes Desmoplastic Stroma and Improves the Antitumor Activity of Chemotherapy in Pancreatic Cancer. 2021,11(5):2182-2200

Cho J, Kinsey D, Kimchi ET, O’Carroll KS, Nguyen V, Alsabbagh M, Gaballah A. Retroperitoneal extra-adrenal myelolipoma misdiagnosed as liposarcoma: A case report. Radiol Case Rep. 2020 Dec 5;16(2):364-368. doi: 10.1016/j.radcr.2020.11.045. eCollection 2021 Feb.

Alan Lu, Junsang Cho, Maryna Vazmitzel, Lester Layfield, Kevin Staveley-O’Carroll, Ayman Gaballah, Deepthi Rao. High-grade appendiceal mucinous neoplasm presenting as a giant appendiceal mucocele. Radiol Case Rep. 2021 Feb 24;16(5):1051-1056. doi: 10.1016/j.radcr.2021.02.014.